Scheduling Status
S2
Product Name
CORENZA-C effervescent tablets
Active Ingredients
Each effervescent tablet contains:
| Active ingredient | Quantity |
|---|---|
| Moroxydine HCl | 100 mg |
| Phenylephrine HCl | 7,5 mg |
| Chlorphenamine maleate | 2 mg |
| Acetylsalicylic acid, also known as aspirin | 500 mg |
| Vitamin C, also known as ascorbic acid | 500 mg |
Sugar and Sweetener Information
CORENZA-C is sugar free.
It contains the sweeteners:
| Sweetener | Quantity per tablet |
|---|---|
| Sodium saccharin | 2,5 mg |
| Mannitol | 200 mg |
Read Before Taking CORENZA-C
CORENZA-C is available without a doctor’s prescription for the treatment of a mild illness. It should still be used carefully to obtain the best results.
Keep the leaflet information for future reference. Do not share CORENZA-C with another person. Ask a healthcare provider or pharmacist if more information or advice is needed.
A doctor should be consulted if symptoms worsen or do not improve after 10 days.
What Is in This Article
- What CORENZA-C is and what it is used for
- What you need to know before you take CORENZA-C
- How to take CORENZA-C
- Possible side effects
- How to store CORENZA-C
- Contents of the pack and other information
1. What CORENZA-C Is and What It Is Used For
CORENZA-C belongs to the group of medicines used for the common cold, including nasal decongestants and antihistamines.
CORENZA-C provides relief from symptoms of colds and flu, including:
| Symptoms relieved |
|---|
| Sneezing |
| Stuffy nose |
| Runny nose |
| Inflammation of the throat |
| Inflammation of the vocal cords |
2. What You Need to Know Before You Take CORENZA-C
Do Not Take CORENZA-C
Do not take CORENZA-C if any of the following apply:
| Do not take CORENZA-C if | Details |
|---|---|
| You are allergic to any active ingredient | This includes moroxydine HCl, phenylephrine HCl, chlorphenamine maleate, acetylsalicylic acid, aspirin, or vitamin C |
| You are allergic to any other ingredient | See the contents section for other ingredients |
| You often suffer from indigestion | CORENZA-C may worsen stomach irritation |
| You have stomach ulcers | Aspirin may increase stomach-related risks |
| You have kidney dysfunction | CORENZA-C may not be suitable |
| You have liver dysfunction | CORENZA-C may not be suitable |
| You have haemophilia | This is a condition where blood does not clot properly |
| You have another bleeding disorder | Aspirin can affect bleeding |
| You have hyperthyroidism | This is an overactive thyroid |
| You have gout | CORENZA-C may not be suitable |
| You have diabetes mellitus | Medical advice is needed |
| You have prostatic hyperplasia | This is enlargement of the prostate gland |
| You have high blood pressure | Phenylephrine may affect blood pressure |
| You have heart conditions | CORENZA-C may not be suitable |
| You have asthma | Aspirin and related medicines may worsen symptoms in some patients |
| You have chronic urticaria | This means long-term hives |
| You have chronic rhinitis | This means long-term swelling and inflammation inside the nose |
| You are hypersensitive to pseudoephedrine or other NSAIDs | Caution is needed |
| You have heart failure | CORENZA-C may not be suitable |
| You have a history of gastric perforation, ulcers, or bleeding linked to anti-inflammatory medicine use | CORENZA-C may increase gastrointestinal risk |
| The patient is under 12 years of age | CORENZA-C should not be used in children under 12 |
| You are 30 weeks or later in pregnancy | NSAIDs such as aspirin may cause problems in the unborn baby |
Warnings and Precautions
Special care is needed with CORENZA-C in several situations.
A doctor should be consulted before giving CORENZA-C to children or teenagers with chickenpox or influenza, due to the risk of Reye’s syndrome associated with aspirin.
Caution is also needed if you have:
| Condition or situation requiring caution |
|---|
| G6PD deficiency |
| Sensitivity to pseudoephedrine hydrochloride |
| Connective tissue disorders |
| Juvenile idiopathic arthritis |
| Planned surgery |
| Advanced age with chronic aspirin use |
| Angle-closure glaucoma |
| Difficulty passing urine |
| Stomach obstruction |
| Phaeochromocytoma |
| History of high blood pressure |
| History of heart failure |
| History of gastrointestinal disease |
| Ulcerative colitis |
| Crohn’s disease |
| Hiatus hernia |
| Gastro-oesophageal reflux disease |
| Angiodysplasia |
CORENZA-C should be stopped several days before scheduled surgery, because aspirin can increase bleeding time.
Chronic use of aspirin in elderly patients should be avoided because of the increased risk of gastric bleeding.
If gastrointestinal bleeding or ulceration occurs, treatment with CORENZA-C should be stopped. Warning signs may include stomach pain, discomfort, vomiting blood, or passing dark stools.
Serious Skin and Hypersensitivity Reactions
Drug Reaction with Eosinophilia and Systemic Symptoms, also called DRESS, has been reported in patients taking NSAIDs such as CORENZA-C.
This reaction may affect the skin, blood, and internal organs. It may be life-threatening or fatal.
Possible signs include:
| Possible signs of DRESS |
|---|
| Fever |
| Rash |
| Enlarged lymph nodes |
| Facial swelling |
| Symptoms resembling an acute viral infection |
| Increased eosinophils |
| Involvement of other organs |
If signs or symptoms of DRESS occur, stop taking CORENZA-C and see a doctor immediately.
Pregnancy Warning
Tell your doctor or healthcare provider if you are pregnant or plan to become pregnant.
Taking NSAIDs such as aspirin in CORENZA-C at around 20 weeks of pregnancy or later may harm the unborn baby.
If NSAID treatment is needed for more than two days between 20 and 30 weeks of pregnancy, a healthcare provider may need to monitor the amount of fluid around the baby.
CORENZA-C should not be taken at around 30 weeks of pregnancy or later.
Other Medicines and CORENZA-C
Always tell your healthcare provider if you are taking any other medicine, including complementary or traditional medicines.
Tell your doctor if you are taking any of the following:
| Medicine or medicine group | Possible concern |
|---|---|
| Iron products | Vitamin C may increase iron absorption in iron-deficient patients |
| Alcohol | Chlorphenamine may increase sedative effects |
| Barbiturates | Sedation may be increased |
| Hypnotics | Sedation may be increased |
| Opioid analgesics | Sedation may be increased |
| Anxiolytic sedatives | Sedation may be increased |
| Antipsychotics | Sedation may be increased |
| Atropine | Additive effects may occur |
| Some antidepressants | Additive effects may occur |
| Aminoglycoside antibacterials | Chlorphenamine may mask signs of ear-related toxicity |
| Monoamine oxidase inhibitors | Phenylephrine may cause very high blood pressure |
| Other NSAIDs such as diclofenac or ibuprofen | Stomach damage risk may increase |
| Corticosteroids | Gastrointestinal bleeding risk may increase |
| Warfarin and other coumarin anticoagulants | Aspirin may increase their activity |
| Sulfonylurea hypoglycaemic medicines | Aspirin may increase their activity |
| Zafirlukast | Aspirin may increase its activity |
| Methotrexate | Aspirin may increase its activity |
| Phenytoin | Aspirin may increase its activity |
| Valproate | Aspirin may increase its activity |
| Probenecid | Its effect may be reduced by aspirin |
| Mifepristone | Aspirin may alter its efficacy |
| Griseofulvin | May interfere with aspirin absorption |
| ACE inhibitors | Aspirin may reduce blood-pressure-lowering effect |
CORENZA-C and Laboratory Tests
Vitamin C in CORENZA-C may interfere with laboratory tests and may cause falsely elevated or false negative results.
CORENZA-C With Food, Drink and Alcohol
CORENZA-C should be taken with food to reduce stomach irritation.
CORENZA-C should not be taken with alcohol, because alcohol may increase side effects and make you feel drowsy.
Pregnancy, Breastfeeding and Fertility
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist, or healthcare provider for advice before taking CORENZA-C.
NSAIDs such as aspirin may harm the unborn baby when used at around 20 weeks of pregnancy or later. CORENZA-C should not be used around 30 weeks of pregnancy or later.
Driving and Using Machines
CORENZA-C may cause drowsiness and impaired concentration.
These effects may be made worse by alcohol or other medicines that depress the central nervous system.
Patients should avoid driving, using machines, or performing tasks requiring alertness until they know how CORENZA-C affects them.
CORENZA-C Contains Sodium
Each effervescent tablet contains 288,11 mg sodium.
This is equivalent to 14,4 % of the recommended maximum daily dietary intake of sodium for an adult.
3. How to Take CORENZA-C
Do not share medicines prescribed for you with another person.
Always take CORENZA-C exactly as described in the leaflet or as directed by a doctor, pharmacist, or nurse.
Recommended Dose
| Patient group | Dose |
|---|---|
| Adults and children older than 12 years | Take 2 tablets immediately, then 1 tablet 3 to 4 times daily as required |
| Children under 12 years | Do not use CORENZA-C |
Method of Use
Drop the tablet into half a glass of cold water. The tablet dissolves quickly and produces an effervescent drink.
Drink the mixture as soon as the effervescing has stopped.
Use the lowest effective dose.
Do not use CORENZA-C for more than 10 days without consulting a doctor.
If You Take More CORENZA-C Than You Should
Possible overdose symptoms may include:
| Possible overdose symptoms |
|---|
| Nausea |
| Dizziness |
| Vomiting |
| Mental clouding |
| Stomach irritation |
| Indigestion |
| Vomiting blood |
| Passing dark, sticky stools containing partly digested blood |
In the event of overdose, consult a doctor or pharmacist. If neither is available, contact the nearest hospital or poison centre.
If You Forget to Take CORENZA-C
Do not take or receive a double dose to make up for forgotten individual doses.
4. Possible Side Effects
CORENZA-C can cause side effects.
Not all side effects reported for CORENZA-C are included here. If your general health worsens or if you experience unexpected effects while taking CORENZA-C, consult your healthcare provider.
Side Effects Table
| Side-effect category | Side effects / symptoms | Recommended action |
|---|---|---|
| Very serious allergic reactions | Swelling of the hands, feet, ankles, face, lips, mouth, or throat; difficulty swallowing or breathing; rash; itching; fainting | Stop taking CORENZA-C and seek urgent medical attention immediately |
| Serious side effects | Chest pain; angina; changes in heartbeat such as faster heartbeat; difficulty breathing; recurrent infections such as fever or sore throat; passing less urine than normal; yellowing of the skin and eyes; dark urine; tiredness that may indicate liver problems | Tell your doctor immediately or go to the nearest casualty department |
| Common side effects | Slight blood loss; anorexia; headache; central nervous system depression such as drowsiness, deep sleep, fatigue, dizziness, or incoordination; swelling; high blood pressure; heart failure; shortness of breath; peptic ulcers; gastrointestinal perforation or bleeding; nausea; vomiting; diarrhoea; flatulence; constipation; indigestion; abdominal pain; dark bloody stools; vomiting blood; inflammation of the mouth; worsening of irritable bowel disease; inflammation of the gastric tract; weakness | Tell your doctor if noticed |
| Uncommon side effects | Agranulocytosis; leukopenia; thrombocytopenia; pancytopenia; aplastic anaemia; haemolytic anaemia; epigastric pain; rashes | Tell your doctor |
| Side effects of unknown frequency | Blood disorders causing increased bleeding time and reduced clotting ability; high blood sugar; lactic acidosis; sleep disturbances; depression and confusion; anxiety or fear; restlessness; insomnia; irritability; psychotic states; convulsions; tingling, numbness, or pins and needles; involuntary muscle contractions; tremor; tinnitus; dry mouth; thickened respiratory-tract secretions; blurred vision; difficulty urinating or urinary retention; constipation; increased gastric reflux or heartburn; Reye’s syndrome; unresponsive dilated pupils; loss of hearing or balance; low blood pressure; stomach discomfort; increased saliva production; liver problems; muscle aches and pain; kidney stones; tolerance after repeated high doses; goosebumps | Tell your doctor or pharmacist |
| Side effects not listed | Any side effect not mentioned or any unexpected health change | Inform your doctor or pharmacist |
Reporting of Side Effects
If side effects occur, speak to a doctor or pharmacist.
Side effects can also be reported to SAHPRA through the Med Safety App and the eReporting platform. Reporting side effects helps provide more information about the safety of CORENZA-C.
5. How to Store CORENZA-C
Store all medicines out of reach of children.
Store CORENZA-C in a cool place at or below 25 °C.
Protect from moisture.
Do not store in a bathroom.
Store in the original container.
Do not use after the expiry date stated on the label.
Return unused medicine to your pharmacist.
Do not dispose of unused medicine in drains or sewerage systems, including toilets.
6. Contents of the Pack and Other Information
What CORENZA-C Contains
The active substances are:
| Active substance | Quantity |
|---|---|
| Moroxydine hydrochloride | 100 mg |
| Phenylephrine HCl | 7,5 mg |
| Chlorphenamine maleate | 2 mg |
| Acetylsalicylic acid, also known as aspirin | 500 mg |
| Vitamin C, also known as ascorbic acid | 500 mg |
Other Ingredients
The other ingredients are:
| Other ingredients |
|---|
| Citric acid anhydrous |
| Docusate sodium |
| Mannitol |
| Polyvidone 30 oral |
| Sodium bicarbonate |
| Sodium carbonate anhydrous |
| Sodium citrate |
| Sodium saccharin |
What CORENZA-C Looks Like and Contents of the Pack
CORENZA-C is a white, cylindrical effervescent tablet with flat faces.
The tablets are packed in aluminium tubes with non-toxic inner coatings and a polyethylene plug containing a desiccant.
Each aluminium tube contains either 10 tablets or 20 tablets.
Holder of Certificate of Registration
Adcock Ingram Limited
1 New Road
Erand Gardens
Midrand, 1685
Customer Care: 0860 ADCOCK / 232625
Leaflet Revision Date
07 February 2025
Registration Number
C661, Act 101/1965
Additional Registration Information
| Country | Registration information |
|---|---|
| Botswana | S3 B9323175 |
| Namibia | NS1 14/5.8/0391 |
Medical Disclaimer
This article is intended as patient information based on the approved leaflet structure. It does not replace advice from a doctor, pharmacist, nurse, or healthcare provider. For regulated medical product use, follow the approved patient information leaflet and healthcare professional guidance.
