{"id":973,"date":"2026-04-23T16:52:46","date_gmt":"2026-04-23T16:52:46","guid":{"rendered":"https:\/\/rxzest.com\/en-za\/?p=973"},"modified":"2026-05-13T11:11:18","modified_gmt":"2026-05-13T11:11:18","slug":"persivate-dosage-side-effects","status":"publish","type":"post","link":"https:\/\/rxzest.com\/en-za\/persivate-dosage-side-effects\/","title":{"rendered":"Persivate in South Africa: Uses, Dosage, Side Effects"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">If you have been prescribed <strong>PERSIVATE<\/strong> and want to understand how to use it safely, this guide walks you through the key points in plain language. PERSIVATE contains <strong>betamethasone valerate<\/strong>, a steroid medicine used on the skin to help calm inflammation, redness and itching linked to certain skin conditions. It comes as an <strong>ointment<\/strong> and a <strong>cream<\/strong>, both with the same active ingredient strength. PERSIVATE is a prescription medicine with <strong>S4 scheduling status<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What it is and what it is used for<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PERSIVATE is a <strong>topical steroid<\/strong> medicine. \u201cTopical\u201d means it is applied to the skin. Steroids in this form help reduce swelling, irritation and itching in the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The active ingredient is <strong>betamethasone valerate<\/strong>. Both the ointment and the cream contain <strong>5 mg betamethasone valerate per 5 g<\/strong> of product.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to the source, PERSIVATE is used to help reduce the <strong>redness and itchiness<\/strong> of certain skin problems, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Eczema<\/strong><\/li>\n\n\n\n<li><strong>Psoriasis<\/strong><\/li>\n\n\n\n<li><strong>Dermatitis<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How it works <\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When your skin is inflamed, it may become red, itchy, sore or swollen. PERSIVATE helps by calming down that inflammation. In simple terms, it reduces the skin\u2019s overactive reaction, which can make the affected area feel more comfortable and look less irritated. This fits with the source description that it is a steroid medicine that reduces swelling and irritation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If your skin condition is flaring up and causing discomfort, this medicine is meant to settle those symptoms. It does not mean every itchy or irritated skin problem should be treated with it, though. Some skin problems can actually get worse with PERSIVATE, especially infections or certain facial rashes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Who should NOT use this medicine<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Do <strong>not<\/strong> use PERSIVATE if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>are <strong>allergic to betamethasone<\/strong> or any of the other ingredients in the product<\/li>\n\n\n\n<li>have a <strong>viral skin infection<\/strong> such as <strong>herpes simplex<\/strong>, <strong>vaccinia<\/strong> or <strong>varicella<\/strong><\/li>\n\n\n\n<li>have a <strong>fungal skin infection<\/strong> such as <strong>candidiasis<\/strong> or <strong>tinea<\/strong><\/li>\n\n\n\n<li>have a <strong>bacterial skin infection<\/strong> such as <strong>impetigo<\/strong><\/li>\n\n\n\n<li>have <strong>tuberculosis (TB) of the skin<\/strong><\/li>\n\n\n\n<li>have <strong>varicose ulcers<\/strong> on the skin near varicose veins<\/li>\n\n\n\n<li>are <strong>pregnant<\/strong><\/li>\n\n\n\n<li>are treating a <strong>child under 1 year of age<\/strong> with it<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The source also says long-term use is <strong>not recommended<\/strong> if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>diabetes<\/strong><\/li>\n\n\n\n<li><strong>tuberculosis (TB)<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Do <strong>not<\/strong> use PERSIVATE to treat the following skin problems, because it may make them worse:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>infected skin<\/strong>, unless the infection is being treated at the same time with an anti-infective medicine<\/li>\n\n\n\n<li><strong>rosacea<\/strong> (severe flushing on and around the nose)<\/li>\n\n\n\n<li><strong>acne vulgaris<\/strong><\/li>\n\n\n\n<li><strong>itching without inflammation<\/strong><\/li>\n\n\n\n<li><strong>itching around the back passage or genitals<\/strong><\/li>\n\n\n\n<li><strong>perioral dermatitis<\/strong> (a spotty red rash around the mouth)<\/li>\n\n\n\n<li><strong>skin infection caused by tuberculosis<\/strong><\/li>\n\n\n\n<li><strong>leg ulcers<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions (Read before use)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before you start using PERSIVATE, there are some important things to keep in mind.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Be careful if you have reacted badly to steroid creams or ointments before<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you have ever had an <strong>allergic reaction to another steroid-type cream or ointment<\/strong>, tell your doctor or pharmacist before using PERSIVATE.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Using too much, for too long, or over large areas can be risky<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you use PERSIVATE <strong>for a long time<\/strong> or over <strong>large areas of skin<\/strong>, your body may absorb too much of the steroid. This may lead to <strong>hypercortisolism<\/strong> or <strong>Cushing\u2019s syndrome<\/strong>, especially in children. These are problems linked to too much cortisol in the body.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Airtight dressings can increase absorption<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you use PERSIVATE <strong>under an airtight dressing<\/strong>, more of the active ingredient can pass through the skin. That can increase the chance of using too much without realising it. The ointment may be used with occlusive dressings, but only as directed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Warning:<\/strong> Do not cover treated areas with airtight dressings unless your healthcare professional has told you to do so.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Extra care is needed on the face, broken skin, skin folds and thin skin<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">You need to take care if you are applying PERSIVATE:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>to the <strong>face<\/strong><\/li>\n\n\n\n<li>on <strong>broken skin<\/strong><\/li>\n\n\n\n<li>in <strong>skin folds<\/strong><\/li>\n\n\n\n<li>on <strong>thin skin<\/strong>, such as the face<\/li>\n\n\n\n<li>on <strong>children<\/strong>, whose skin may absorb more than adult skin<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Avoid getting it into the eyes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If PERSIVATE is used <strong>near the eyes or on the eyelids<\/strong>, repeated entry into the eye may lead to <strong>cataracts<\/strong> or <strong>glaucoma<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Psoriasis needs closer supervision<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you have <strong>psoriasis<\/strong>, PERSIVATE could aggravate it. The source says your doctor will need to see you more often.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Skin infections need treatment too<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you have a <strong>skin infection<\/strong>, it will need to be treated. PERSIVATE should not simply be used on infected skin without proper management.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Stopping suddenly after long use can cause rebound symptoms<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you use PERSIVATE for a long time, stopping may lead to <strong>rebound flares<\/strong> or <strong>topical steroid withdrawal syndrome<\/strong>. Symptoms can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>intense redness<\/li>\n\n\n\n<li>stinging<\/li>\n\n\n\n<li>burning<\/li>\n\n\n\n<li>symptoms spreading beyond the original treatment area<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> The source advises not to stop treatment early or abruptly, because sudden withdrawal may also result in <strong>glucocorticosteroid insufficiency<\/strong>, where the body does not produce enough cortisol.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Children<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source says there is <strong>no experience with PERSIVATE in infants and young children<\/strong>. It also says use in children <strong>under 12 years<\/strong> should be limited to <strong>five days<\/strong>. PERSIVATE should <strong>not be used in infants and young children<\/strong>, and it should not be used in <strong>children below 1 year of age<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Driving and using machines<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PERSIVATE can cause <strong>blurred vision<\/strong>, and that may affect your ability to <strong>drive or use machines<\/strong>. The source says you should avoid these activities until you know how the medicine affects you.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Important ingredient warning<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The cream contains <strong>chlorocresol<\/strong>, which can cause <strong>allergic reactions<\/strong>. If that happens, PERSIVATE should be stopped.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, planning pregnancy, and breastfeeding<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">You should <strong>not use PERSIVATE if you are pregnant or breastfeeding<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>pregnant<\/li>\n\n\n\n<li>breastfeeding<\/li>\n\n\n\n<li>think you may be pregnant<\/li>\n\n\n\n<li>planning to have a baby<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">speak to your doctor, pharmacist or another healthcare provider before using this medicine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Information about fertility is <strong>not specified in the source<\/strong>. Speak to your doctor or pharmacist before use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Interactions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Always tell your healthcare provider about <strong>all other medicines<\/strong> you are taking. This includes <strong>complementary<\/strong> or <strong>traditional medicines<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The source specifically mentions that you should tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ritonavir<\/strong> (used to treat HIV infection)<\/li>\n\n\n\n<li><strong>Itraconazole<\/strong> (used to treat fungal infections)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Food interactions are <strong>not specified in the source<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alcohol interactions are <strong>not specified in the source<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interactions with medical tests are <strong>not specified in the source<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take (Step-by-step)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Use PERSIVATE exactly as your doctor or pharmacist has told you. Do not share it with anyone else, even if their skin problem looks similar to yours.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">General directions<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PERSIVATE is for <strong>external use only<\/strong>.<\/li>\n\n\n\n<li>Apply it to the <strong>affected areas<\/strong>.<\/li>\n\n\n\n<li>Rub it in <strong>gently<\/strong>.<\/li>\n\n\n\n<li>Use it for the length of time your doctor tells you.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Usual dose for the ointment<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">For <strong>PERSIVATE OINTMENT<\/strong>, apply it to the affected areas <strong>2 or 3 times daily<\/strong> by gentle rubbing, or use it with <strong>occlusive dressings<\/strong> if directed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Usual dose for the cream<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">For <strong>PERSIVATE cream<\/strong>, apply it to the affected areas <strong>2 to 3 times daily<\/strong> by gently rubbing.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Use in children<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PERSIVATE <strong>should not be used on infants and young children<\/strong>.<\/li>\n\n\n\n<li>In children <strong>under 12 years<\/strong>, treatment duration should be limited to <strong>five days<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Do not stop suddenly<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Do not stop treatment <strong>early<\/strong> or <strong>abruptly<\/strong>, especially if you have been using it for longer periods. Sudden stopping may cause problems such as <strong>glucocorticosteroid insufficiency<\/strong> or a <strong>withdrawal reaction<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">If the effect feels too strong or too weak<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you feel PERSIVATE is working too strongly or not strongly enough, tell your doctor or pharmacist.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">If you use more than you should<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In the event of an <strong>overdose<\/strong>, consult your doctor or pharmacist. If neither is available, contact the <strong>nearest hospital<\/strong> or <strong>poison control centre<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">If you forget a dose<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you miss an application:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>apply it <strong>as soon as you remember<\/strong><\/li>\n\n\n\n<li>if it is <strong>nearly time for the next application<\/strong>, skip the missed one<\/li>\n\n\n\n<li><strong>do not apply a double dose<\/strong> to make up for the missed application<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If you have forgotten to apply <strong>several applications<\/strong>, contact your doctor <strong>without delay<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Simple adherence tips based on the source<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">To help you use PERSIVATE safely:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>apply it only to the areas your doctor has told you to treat<\/li>\n\n\n\n<li>keep to the number of applications prescribed<\/li>\n\n\n\n<li>avoid stopping suddenly unless your doctor tells you to<\/li>\n\n\n\n<li>if you miss several doses, contact your doctor promptly<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Dosing table<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Product<\/th><th>Age or group<\/th><th>Dose<\/th><th>Frequency<\/th><th>Maximum daily dose<\/th><th><\/th><\/tr><\/thead><tbody><tr><td>PERSIVATE OINTMENT<\/td><td>Adults and groups not otherwise excluded in the source<\/td><td>Apply to affected areas by gentle rubbing; may also be used with occlusive dressings if directed<\/td><td>2 or 3 times daily<\/td><td>Not specified in the source<\/td><td><\/td><\/tr><tr><td>PERSIVATE cream<\/td><td>Adults and groups not otherwise excluded in the source<\/td><td>Apply to affected areas by gentle rubbing<\/td><td>2 to 3 times daily<\/td><td>Not specified in the source<\/td><td><\/td><\/tr><tr><td>Children under 12 years<\/td><td>Children under 12 years<\/td><td>Not separately quantified in the source<\/td><td>Not separately stated beyond usual application frequency<\/td><td>Treatment duration should be limited to 5 days<\/td><td><\/td><\/tr><tr><td>Infants and young children \/ children below 1 year<\/td><td>Do not use<\/td><td>Do not use<\/td><td>Do not use<\/td><td>Do not use<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Not everyone gets side effects, but it is important to know what to look out for. If your general health becomes worse or you notice anything unusual while using PERSIVATE, speak to your healthcare provider.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source lists the following as <strong>frequent<\/strong> side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>burning<\/strong> where the medicine is applied<\/li>\n\n\n\n<li><strong>pain<\/strong> where it is applied<\/li>\n\n\n\n<li><strong>itching<\/strong> where it is applied<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Less common<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source lists the following as <strong>less frequent<\/strong> side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>increased risk of <strong>infection<\/strong><\/li>\n\n\n\n<li><strong>allergic skin reactions<\/strong><\/li>\n\n\n\n<li><strong>skin irritation<\/strong> or pain where applied<\/li>\n\n\n\n<li><strong>rash<\/strong><\/li>\n\n\n\n<li><strong>itchy bumpy skin<\/strong><\/li>\n\n\n\n<li><strong>redness of the skin<\/strong><\/li>\n\n\n\n<li>lowered <strong>cortisol<\/strong> levels linked to <strong>HPA axis suppression<\/strong><\/li>\n\n\n\n<li><strong>Cushingoid features<\/strong><\/li>\n\n\n\n<li><strong>delayed weight gain<\/strong> or <strong>growth retardation in children<\/strong><\/li>\n\n\n\n<li><strong>osteoporosis<\/strong><\/li>\n\n\n\n<li><strong>glaucoma<\/strong><\/li>\n\n\n\n<li>raised <strong>blood sugar<\/strong> or <strong>sugar in the urine<\/strong><\/li>\n\n\n\n<li><strong>cataract<\/strong><\/li>\n\n\n\n<li><strong>high blood pressure<\/strong><\/li>\n\n\n\n<li><strong>increased weight<\/strong>, <strong>obesity<\/strong> or <strong>rounding of the face<\/strong><\/li>\n\n\n\n<li>changes in hair growth, including <strong>hair loss<\/strong> or increased hair growth<\/li>\n\n\n\n<li><strong>thinning<\/strong> or <strong>dryness<\/strong> of the skin<\/li>\n\n\n\n<li><strong>skin wrinkling<\/strong><\/li>\n\n\n\n<li><strong>stretch marks<\/strong><\/li>\n\n\n\n<li>more visible small blood vessels under the skin<\/li>\n\n\n\n<li>changes in skin colour<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Serious\u2014seek urgent help<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Stop using PERSIVATE and get urgent medical help if you develop signs of a <strong>serious allergic reaction<\/strong>, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>swelling of the hands, feet, ankles, face, lips, mouth or throat<\/li>\n\n\n\n<li>difficulty swallowing<\/li>\n\n\n\n<li>difficulty breathing<\/li>\n\n\n\n<li>rash or itching<\/li>\n\n\n\n<li>fainting<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">You should also seek urgent medical attention if you notice:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>raised bumps with pus under the skin<\/strong> if you have psoriasis<\/li>\n\n\n\n<li>signs linked to <strong>build-up of pressure around the brain<\/strong> (described in the source as benign intracranial hypertension)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Side effects with unknown frequency<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source also lists side effects where the frequency is not known:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>blurred vision<\/strong><\/li>\n\n\n\n<li><strong>steroid withdrawal reaction<\/strong> after prolonged continuous use, including:<\/li>\n\n\n\n<li>redness extending beyond the original treated area<\/li>\n\n\n\n<li>burning or stinging<\/li>\n\n\n\n<li>intense itching<\/li>\n\n\n\n<li>peeling skin<\/li>\n\n\n\n<li>oozing open sores<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Reporting side effects in South Africa<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">If you get side effects, speak to your doctor, pharmacist or nurse. You can also report side effects to <strong>SAHPRA<\/strong> through the <strong>Med Safety APP (Medsafety X SAHPRA)<\/strong> and the <strong>eReporting platform<\/strong> listed on the SAHPRA website. The source also provides Aspen Pharmacare contact details for drug safety reporting.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Storage and disposal<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To store PERSIVATE safely:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>keep it <strong>out of reach of children<\/strong><\/li>\n\n\n\n<li>store it in an <strong>airtight container<\/strong><\/li>\n\n\n\n<li>store at or below <strong>25 \u00b0C<\/strong><\/li>\n\n\n\n<li><strong>protect from light<\/strong><\/li>\n\n\n\n<li>keep it in the <strong>original packaging<\/strong> until you need to use it<\/li>\n\n\n\n<li><strong>do not store it in a bathroom<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Do not use it after the <strong>expiry date<\/strong> on the label.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For disposal:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>return <strong>unused medicine<\/strong> to your pharmacist<\/li>\n\n\n\n<li>do <strong>not<\/strong> throw unused medicine into <strong>drains<\/strong> or <strong>sewerage systems<\/strong>, such as the toilet<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine contains<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Active ingredient<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The active ingredient is:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>betamethasone valerate 5 mg per 5 g<\/strong> cream or ointment<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Other ingredients in the ointment<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PERSIVATE OINTMENT contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>beeswax white<\/li>\n\n\n\n<li>cholesterol<\/li>\n\n\n\n<li>propylene glycol<\/li>\n\n\n\n<li>stearyl alcohol<\/li>\n\n\n\n<li>white soft paraffin<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Other ingredients in the cream<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PERSIVATE cream contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>cetyl alcohol<\/li>\n\n\n\n<li>chlorocresol<\/li>\n\n\n\n<li>citric acid monohydrate<\/li>\n\n\n\n<li>disodium hydrogen phosphate<\/li>\n\n\n\n<li>emulsifying wax<\/li>\n\n\n\n<li>liquid paraffin<\/li>\n\n\n\n<li>propylene glycol<\/li>\n\n\n\n<li>purified water<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Preservative<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source states that the cream contains the preservative:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>chlorocresol 1% m\/m<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pack information and appearance<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">What it looks like<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PERSIVATE OINTMENT<\/strong> is described as a <strong>soft, smooth, translucent whitish ointment<\/strong><\/li>\n\n\n\n<li><strong>PERSIVATE cream<\/strong> is described as a <strong>soft, smooth, homogenous, white cream<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Pack sizes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">For both the ointment and the cream, the source says:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>15 g<\/strong> pack: aluminium collapsible tube with a white self-piercing high-density polyethylene screw-cap, packed in a unit cardboard carton<\/li>\n\n\n\n<li><strong>500 g<\/strong> pack: white round high-density polyethylene jar with a white polypropylene screw-cap<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Not all packs and pack sizes are necessarily marketed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">South African registration details<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source lists the following registration numbers:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PERSIVATE OINTMENT:<\/strong> L\/13.4.1\/395<\/li>\n\n\n\n<li><strong>PERSIVATE cream:<\/strong> L\/13.4.1\/382<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Practical FAQs (based ONLY on the source)<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Can I use PERSIVATE on any itchy rash?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. The source says there are several skin problems where PERSIVATE should not be used, including infected skin unless it is being treated appropriately, rosacea, acne, itching without inflammation, genital or anal itching, perioral dermatitis, TB skin infection and leg ulcers.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I use it if I am pregnant?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. The source clearly says you should not use PERSIVATE if you are pregnant.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I breastfeed while using it?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. The source says you should not use PERSIVATE if you are breastfeeding your baby.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I use it on my child?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The source says PERSIVATE should not be used in <strong>infants and young children<\/strong>, and it should not be used in <strong>children below 1 year of age<\/strong>. In children under 12 years, duration of use should be limited to <strong>five days<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What must I do if I forget to apply it?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Apply the missed dose as soon as you remember. If it is nearly time for your next application, skip the missed one. Do not apply a double dose. If you missed several applications, contact your doctor without delay.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What if I accidentally use too much?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Consult your doctor or pharmacist. If they are not available, contact the nearest hospital or poison control centre.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I stop as soon as my skin looks better?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Not on your own. The source says not to stop treatment early or abruptly, because sudden withdrawal may cause glucocorticosteroid insufficiency, and long-term inappropriate use can also lead to rebound flares after stopping.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I drive while using PERSIVATE?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Maybe not straight away. PERSIVATE can cause blurred vision, so you should not drive or use machines until you know how it affects you.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I drink alcohol while taking this?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Not specified in the source.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I use it near my eyes?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">You should be very careful. Repeated exposure of the eyes to PERSIVATE may lead to cataracts or glaucoma if it repeatedly enters the eye.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Plain-language summary<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">If you are using <strong>PERSIVATE (betamethasone valerate)<\/strong>, it is there to help settle skin inflammation, redness and itching in conditions such as eczema, psoriasis and dermatitis. Use it only on the skin, exactly as prescribed, and only for the condition it was given for. Do not use it on skin infections, certain facial rashes, or in pregnancy or breastfeeding, because the source specifically warns against this.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seek medical help urgently if you develop swelling, trouble breathing, fainting, or other signs of a serious allergic reaction. Also get advice promptly if your skin becomes intensely red, burns, stings or worsens after stopping, especially after longer use. Store the medicine below 25 \u00b0C, protect it from light, keep it away from children, and return unused medicine to your pharmacist rather than throwing it into the toilet or drain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you have been prescribed PERSIVATE and want to understand how to use it safely, this guide walks you through the key points in plain language. PERSIVATE contains betamethasone valerate, a steroid medicine used on the skin to help calm inflammation, redness and itching linked to certain skin conditions. It comes as an ointment and &#8230; <a title=\"Persivate in South Africa: Uses, Dosage, Side Effects\" class=\"read-more\" href=\"https:\/\/rxzest.com\/en-za\/persivate-dosage-side-effects\/\" aria-label=\"Read more about Persivate in South Africa: Uses, Dosage, Side Effects\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":975,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions"],"_links":{"self":[{"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/posts\/973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/comments?post=973"}],"version-history":[{"count":2,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/posts\/973\/revisions"}],"predecessor-version":[{"id":1258,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/posts\/973\/revisions\/1258"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/media\/975"}],"wp:attachment":[{"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/media?parent=973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/categories?post=973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxzest.com\/en-za\/wp-json\/wp\/v2\/tags?post=973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}