Use within 14 days of stopping monoamine oxidase inhibitors<\/td><\/tr>
Use with tricyclic antidepressants<\/td><\/tr>
Late pregnancy where sympathomimetic amines are inadvisable<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
8. Warnings and Special Precautions<\/h3>\n\n\n\n
HISTACON CAPSULES should not be used continuously for more than 10 days without consulting a doctor.<\/p>\n\n\n\n
The medicine may cause drowsiness and impaired concentration. These effects may be worsened by alcohol or other central nervous system depressants. Patients who are affected should avoid driving, operating machinery, or performing hazardous tasks.<\/p>\n\n\n\n
Special precautions include:<\/p>\n\n\n\n
Ingredient \/ area<\/th>
Precaution<\/th><\/tr><\/thead>
Paracetamol<\/td>
Use caution in kidney or liver impairment<\/td><\/tr>
Phenylephrine<\/td>
Use caution in cardiovascular disease, diabetes, glaucoma, and hyperthyroidism<\/td><\/tr>
Chlorphenamine<\/td>
Use caution in narrow-angle glaucoma, urinary retention, and prostatic hypertrophy<\/td><\/tr>
Caffeine<\/td>
Use caution in peptic ulceration, hypertension, hyperthyroidism, cardiac arrhythmias, hepatic dysfunction, chronic alcoholism, lung disease, and older patients<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
May affect medicines eliminated by the liver<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
10. Human Reproduction<\/h3>\n\n\n\n
Use<\/th>
Recommendation<\/th><\/tr><\/thead>
Pregnancy<\/td>
Should not be used<\/td><\/tr>
Lactation<\/td>
Should not be used<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
11. Dosage and Directions for Use<\/h3>\n\n\n\n
Patient group<\/th>
Dose<\/th><\/tr><\/thead>
Adults<\/td>
One to two capsules four times per day<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
12. Side Effects<\/h3>\n\n\n\n
Possible side effects listed for the active ingredients include:<\/p>\n\n\n\n
Ingredient<\/th>
Possible side effects<\/th><\/tr><\/thead>
Paracetamol<\/td>
Allergic skin reactions and blood disorders<\/td><\/tr>
Phenylephrine<\/td>
Central nervous system effects and cardiovascular effects<\/td><\/tr>
Chlorphenamine<\/td>
Sedation, gastrointestinal effects, antimuscarinic effects, paradoxical central nervous system stimulation, seizures, and blood disorders<\/td><\/tr>
Caffeine<\/td>
Gastrointestinal irritation, central nervous system stimulation, insomnia, headache, anxiety, tremor, sleeplessness, and palpitations<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
13. Overdosage<\/h3>\n\n\n\n
The document gives detailed overdose information, especially for paracetamol.<\/p>\n\n\n\n
Immediate medical consultation or hospital care is required in overdose.<\/p>\n\n\n\n
Treatment described includes urgent specialised care, gastric lavage in certain cases, and antidote therapy such as acetylcysteine or methionine. The document provides intravenous and oral acetylcysteine regimens and states that acetylcysteine is effective if administered within 8 hours of overdose.<\/p>\n\n\n\n
14. Identification<\/h3>\n\n\n\n
Item<\/th>
Description<\/th><\/tr><\/thead>
Capsule type<\/td>
Opaque gelatin capsule<\/td><\/tr>
Size<\/td>
No. 1<\/td><\/tr>
Cap colour<\/td>
Blue<\/td><\/tr>
Body colour<\/td>
White<\/td><\/tr>
Contents<\/td>
Fine white powdery granulate<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
15. Presentation<\/h3>\n\n\n\n
Item<\/th>
Details<\/th><\/tr><\/thead>
Pack size<\/td>
1,000 capsules<\/td><\/tr>
Container<\/td>
White high-density polyethylene jar<\/td><\/tr>
Closure<\/td>
White flat cap<\/td><\/tr>
Liner<\/td>
Low-density polyethylene liner<\/td><\/tr>
Insert<\/td>
White foam insert<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
16. Storage Instructions<\/h3>\n\n\n\n
Storage requirement<\/th><\/tr><\/thead>
Store at or below 25 \u00b0C<\/td><\/tr>
Store in a dry place<\/td><\/tr>
Keep well closed<\/td><\/tr>
Keep in the original packaging until required<\/td><\/tr>
Keep out of reach of children<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
17. Registration and Holder<\/h3>\n\n\n\n
Item<\/th>
Details<\/th><\/tr><\/thead>
Registration number<\/td>
C839<\/td><\/tr>
Act<\/td>
Act 101\/1965<\/td><\/tr>
Holder of certificate of registration<\/td>
Pharmacare Limited<\/td><\/tr>
Address<\/td>
Healthcare Park, Woodlands Drive, Woodmead 2191<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
18. Publication Information<\/h3>\n\n\n\n
Item<\/th>
Details<\/th><\/tr><\/thead>
Date of registration<\/td>
Old medicine<\/td><\/tr>
Most recent amendment approved by the Authority<\/td>
01 September 1970<\/td><\/tr>
Other registration details<\/td>
Botswana and Namibia registration details are listed in the original professional information document<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"